Project’s title:
„Bioconjugates labeled with alpha- and beta-particle emitting radionuclides as potential radiopharmaceuticals in Targeted Radionuclide Therapy”

Project’s no:
2019/34/E/ST4/00080

Project’s PI:
Marek Pruszyński, PhD, DSc, prof. ICHTJ

Job title:
PhD Student - Scholar

Requirements:

• a PhD student currently enrolled in a Doctoral School or a master's degree holder in chemistry, biology, biotechnology, or a related field;
• proficiency in English (spoken and written) for effective communication and preparation of scientific articles;
• strong motivation for scientific work and the ability to acquire new knowledge and technical skills;
• good communication skills and the ability to work in an international research team.

Description of tasks:

• participation in research work under the NCN SONATA-BIS9 – a short description of the project is presented below:
  “Cancer is the second leading cause of deaths in the world and its incidence steadily increases. Although incremental success have been achieved with more selective therapies targeting biomarkers typical for a cancer cell, still a large part of patients cannot be cured. Incomplete eradication of residual tumor cells and acquired drug resistance influence on relapse and progression of disease, especially in very aggressive and metastatic breast, ovarian and gastric cancers overexpressing HER2 receptor. Targeted radionuclide therapy (TRT) uses radionuclides attached to cancer-specific molecules to selectively deliver radiation to the tumor. The aim of this project is to develop novel radiobioconjugates based on anti-HER2 biomolecules labeled with α- and β-particle emitting radionuclides as potential new radiopharmaceuticals for TRT.”
• participation in the preparation of bioconjugates based on biomolecules with attached chelating ligands such as: DOTA, DTPA, DFO etc., which then will be labeled with radioactive isotopes, e.g. Ac-225, Th-227, I-131, Y-90 etc.;
• preparation of bioconjugates based on biomolecules with attached chelating ligands such as DOTA, DTPA, DFO, etc., which will be labeled with radioactive isotopes like Ac-225, Lu-177, or Y-90;
• conducting preliminary in vitro biological studies on cancer cells;
• writing reports, publication and conference abstracts.

Deadline for submitting documents: 4th November 2024 23:59 CET

Terms of employment:

• scholarship of 2500 PLN per month for a period of 17 months;
• interdisciplinary cooperation with national (e.g. National Centre for Nuclear Research, University of Warsaw) and international scientific institutions (e.g. Vrije Universiteit Brussel, Czech Technical University, Duke University – Durham/USA);
• opportunities for professional development within the position;
• work with the use of modern research equipment.

Recruitment procedure:

• e-mail – please send documents to the Principal Investigator Marek Pruszyński, PhD, DSc: m.pruszynski@ichtj.waw.pl with the title of the email: “PhD Student Scholarship position project No 2019/34/E/ST4/00080” (emails without this title will not be considered);
• top candidates will be invited for an online or in-person interview. Good command of English is required. We reserve the right to contact and reply to only selected candidates;
• the incomplete applications will be not considered.

Required documents:

• CV presenting the candidate’s scientific achievements and experience;
• motivation letter;
• transcript of grades from first/second-cycle studies;
• copy of the master’s or engineer’s degree.

1. The Controller of your personal data is the Institute of Nuclear Chemistry and Technology in Warsaw at 16 Dorodna Street, 03-195 Warsaw, hereinafter referred to as the Controller.
2. The Controller has appointed a Data Protection Officer. The Controller or the Data Protection Officer can be contacted via email address: iod@ichtj.waw.pl
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