Electron spin resonance (epr/esr) studies on stable paramagnetic centers produced in mineralized tissues by ionizing radiation are surveyed. Stability, dose-dependence and nature of epr signals in crystalline constituent of bone mineral exposed to radiation are discussed, Numerous applications based on the detection of epr signals assigned to radiation induced paramagnetic centers and the evaluation of spin concentration by carrying out quantitative epr measurements in mineralized tissues and other solid components of biological systems are shown. Biomedical applications refer to transplantology, physiology and pathology while other ones are addressed to dosimetry and detection of the irradiated food.