NUKLEONIKA 2005, 50(Supplement 2):S13-S16
Aneta Cheda, Jolanta Wrembel-Wargocka, Ewa M. Nowosielska, Marek K. Janiak
Military Institute of Hygiene and Epidemiology,
Department of Radiobiology and Radiation Protection,
4 Kozielska Str., 01-163 Warsaw, Poland
A number of epidemiological and experimental data indicate that exposures to low doses of low-LET
ionising radiation may trigger the activity of natural anti-tumour immune mechanisms and inhibit
tumour growth. In the present study, we assessed the cytotoxic activity and production of nitric oxide,
superoxide anions, and tumour necrosis factor-a in peritoneal macrophages
collected from BALB/c mice exposed to single whole-body irradiations with 0.1, 0.2, or
1.0 Gy X-rays. The results indicate that all the tested parameters were significantly up-regulated
in macrophages obtained from mice exposed to 0.1 or 0.2 Gy X-rays but not in those collected from the
sham-irradiated and 1.0 Gy-exposed animals.