NUKLEONIKA 2006, 51(3):155-159
Amir R. Jalilian, Pejman Rowshanfarzad, Mahsheed Sabet, Ali Rahiminejad-Kisomi, Amir A. Rajamand
Atomic Energy Organization of Iran (AEOI), Nuclear Research Center for Agriculture
and Medicine (NRCAM), Moazzen Blvd., Rajaee shahr, Karaj, Iran,
P. O. Box 31485-498
The aim of this work is development of a possible blood cell labeling agent for ultimate use in PET.
Gallium-66 (T1/2 = 9.49 h) is an interesting radionuclide that has a potential for
positron emission tomography (PET) imaging of biological processes with intermediate to slow target
tissue uptake. Oxine has been labeled with this radionuclide in the form of [66Ga]gallium
chloride for its possible diagnostic properties. In this study, 66Ga was produced at a 30 MeV
cyclotron (IBA-Cyclone 30) via the 66Zn(p,n)66Ga reaction. The production yield
was 445.5 MBq/mAh. The [66Ga]oxine complex was obtained
at pH = 5 in phosphate buffer medium at 37°C in 10 min. Radio-TLC showed a radiochemical purity of
more than 98 ± 2%. The chemical stability of the complex was checked in vitro with a specific activity of
1113 GBq/mmol. The serum stability and log P of the complex were calculated. The produced
[66Ga]oxine can be used for diagnostic studies, due to its desirable physico-chemical
properties both in vitro and in vivo according to internationally accepted limits.