NUKLEONIKA 2006, 51(4):203-208
Amir R. Jalilian1, Mohammad A. Hosseini2, Alireza Karimian1, Fariba Saddadi1, Mahdi Sadeghi1
1 Cyclotron and Nuclear Medicine Department,
Nuclear Research Center for Agriculture and Medicine (NRCAM),
Atomic Energy Organization of Iran (AEOI), Moazzen Blvd., Rajaee shahr, Karaj, Iran,
P. O. Box 31485-498
2 Science and Research Unit, Islamic Azad University,
P. O. Box 14155-775, Postal code 1477893855, Tehran, Iran
Thallium-201 (T1/2 = 3.04 days) in Tl+ form was converted to Tl3+
cation in presence of O3 in 6 M HCl controlled by RTLC/gel electrophoresis methods.
The final evaporated activity was reacted with vancomycin (VAN) in water to yield [201Tl](III)VAN.
The best results were obtained at room temperature in water after 30 min with
a radiochemical yield > 99%, after mixing the reactants followed by SPE purification using Si Sep-Pak.
The studies showed that thallic ion is mostly incorporated into vancomycin with a radiochemical purity
of more than 98 ± 1% by RTLC. A specific activity of about 4.14 ´ 1010 Bq/mmol
was obtained. Radiochemical purity and stability of 201Tl-VAN in the preparation and
in presence of human serum was determined up to 5.5 days. Biodistribution study of
201Tl(III)-vancomycin in normal rats was performed up to 52 h.